[Structural remodeling of the renal vascular bed in experimental stenosis of the pulmonary trunk]. / Strukturnoe remodelirovanie sosudistogo basseina pochek pri éksperimental'nom stenoze legochnogo stvola.

ABSTRACT

A hemodynamic model of the pulmonary trunk stenosis was created in the experiment that involved twenty two pups to reveal the regularities of the structural changes in the different areas of the renal vascular bed. The animals were monitored from the six months up to two years of age. Specimens obtained from different parts of their kidneys were investigated histologically, histochemically, morphometrically and stereometrically. The material taken from ten dogs of the corresponding age was used for control. It was found that the establishment of pulmonary trunk stenosis and the impairment of the blood outflow from the kidneys was followed by a structural remodeling of all the regions of renal vascular bed. This process included the hyperplasia and hypertrophy of the smooth myocytes in the media of the vascular wall as well as migration of these cells into the intima with the formation of specialized structures, regulating the hemodynamics, as well as the accumulation of the extracellular matrix in the walls of renal arteries and veins.