Subcellular localization of two neurotropic drugs in three varieties of central nervous system cells by secondary ion mass spectroscopy (SIMS) microscopy.
Biol Cell
; 74(1): 99-103, 1992.
Article
em En
| MEDLINE
| ID: mdl-1511253
ABSTRACT
The intracellular localization of two neurotropic drugs, flunitrazepam (benzodiazepine) and triflupromazine (phenothiazine), was studied by secondary ion mass spectrometry microscopy (SIMS) in three varieties of cells. The images of the intracellular distributions of the two drugs are easily obtained by selecting the fluorine atom of the molecules. These images show that the drug from the benzodiazepine group is mainly located in the nuclei, whereas the phenothiazine is exclusively located inside the cytoplasm.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Triflupromazina
/
Sistema Nervoso Central
/
Flunitrazepam
/
Microscopia
Limite:
Animals
Idioma:
En
Revista:
Biol Cell
Ano de publicação:
1992
Tipo de documento:
Article