The uveitogenic potential of retinal S-antigen in horses.
Invest Ophthalmol Vis Sci
; 45(7): 2286-92, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15223807
ABSTRACT
PURPOSE:
To investigate the uveitogenic potential of retinal S-antigen (S-Ag) in horses.METHODS:
Horses were immunized subcutaneously with S-Ag or BSA as control antigen, emulsified in complete Freund's adjuvant. Simultaneously, Bordetella pertussis was given intravenously. Antigen specific T- and B-cell responses were analyzed in a 3-day interval. Disease development was judged clinically and histopathologically. Two identical booster immunizations were given every 4 weeks to test induction of recurrences.RESULTS:
T- and B-cell responses specific for S-Ag were observed in all immunized horses but were absent in control animals. However, uveitis developed in only one of five animals. Reimmunization with S-Ag did not lead to a uveitic relapse in this horse. All other horses of the S-Ag- and BSA-treated groups neither showed any signs of uveitis, nor had inflammatory infiltrates of the inner eye.CONCLUSIONS:
In contrast to interphotoreceptor retinoid-binding protein (IRBP), S-Ag is a weak autoantigen in horses. Even though S-Ag immunization leads to the activation of autoreactive T- and B-cells, infiltration of the inner eye and induction of uveitis are controlled in most horses.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
/
Doenças Autoimunes
/
Uveíte
/
Arrestina
/
Doenças dos Cavalos
Limite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Ano de publicação:
2004
Tipo de documento:
Article