In vivo inhibition of basal and estrogen-induced phospholipase A2 activities by the triphenylethylene antiestrogen, tamoxifen, in immature quail oviduct.
Eur J Pharmacol
; 216(1): 127-30, 1992 May 27.
Article
em En
| MEDLINE
| ID: mdl-1526252
ABSTRACT
The effects of tamoxifen on oviductal phospholipase A2 activity were studied in immature quails. Injected alone, from 0.1 to 10 mg/kg tamoxifen significantly reduced basal phospholipase A2 activity 6 h after the injection, independently of the dose used. At 24 h, maximal inhibition (-50%) was observed with 0.1 mg/kg tamoxifen, while higher doses were less effective. Combined with estradiol benzoate, tamoxifen reduced even below the control value (1 mg/kg for 24 h) the increase in phospholipase A2 activity induced by estrogen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oviductos
/
Fosfolipases A
/
Tamoxifeno
/
Divisão Celular
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article