Modulating angiogenesis: more vs less.
JAMA
; 292(8): 972-7, 2004 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-15328330
ABSTRACT
The concept of manipulation of the vascular bed to either increase or decrease the number of blood vessels has attracted considerable interest. This review focuses on angiogenesis as a therapeutic target, particularly in the context of cancer and arthritis, as well as on promoting angiogenesis in cardiovascular disease and the healing of bone fractures. Although once touted almost as a panacea for treatment of tumors, as well as other diseases associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis, it is now clear that such enthusiasm was somewhat premature. Similarly, some clinical trials of therapeutic angiogenesis for the management of cardiovascular disease have been disappointing. Nevertheless, this exciting field of research holds promise for more targeted therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neovascularização Fisiológica
/
Inibidores da Angiogênese
/
Indutores da Angiogênese
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
JAMA
Ano de publicação:
2004
Tipo de documento:
Article