Ras/Raf/ERK signalling and NF1.
Cell Cycle
; 3(10): 1255-8, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15467460
ABSTRACT
Ras signalling is important in the development of Schwann-cell-derived tumors in Neurofibromatosis Type 1 (NF1) patients. Schwann cells are a regenerative cell type, with no known stem-cell population. To produce new cells in the adult, for example following nerve damage, myelinating Schwann cells de-differentiate, proliferate and then re-differentiate during the repair process. We have found that Ras/Raf/ERK signalling can drive the de-differentiation of myelinated Schwann cells. In this review, we discuss how our results may contribute to the understanding of tumor formation in NF1 patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas Proto-Oncogênicas p21(ras)
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Neurofibromina 1
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Proteínas Oncogênicas v-raf
/
MAP Quinases Reguladas por Sinal Extracelular
Limite:
Humans
Idioma:
En
Revista:
Cell Cycle
Ano de publicação:
2004
Tipo de documento:
Article