Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway.
Arch Virol
; 149(11): 2235-44, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15503209
ABSTRACT
Adoptive transfer studies were performed to test the hypothesis that the perforin cytotoxic pathway is more important than the Fas/FasL cytotoxic pathway in protection against experimental murine cytomegalovirus (MCMV) retinitis. Splenic immune cells from donor MCMV-immunized normal mice or gld mice deficient in Fas/FasL-mediated cytotoxicity significantly reduced the frequency and severity of MCMV retinitis following subretinal MCMV challenge when transferred into recipient PKO mice deficient in perforin-mediated cytotoxicity. In sharp contrast, splenic cells from donor MCMV-immunized PKO mice failed to provide protection against MCMV retinitis when transferred into recipient PKO mice. Protection was not achieved, however, in recipient mice with retrovirus-induced immunodeficiency (MAIDS), even when splenic cells originated from MCMV-immunized normal mice.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Síndrome de Imunodeficiência Adquirida Murina
/
Muromegalovirus
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Retinite por Citomegalovirus
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Transferência Adotiva
/
Citotoxicidade Imunológica
Limite:
Animals
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2004
Tipo de documento:
Article