Urinary excretion of vascular endothelial growth factor is increased in children with reflux nephropathy.
Nephron Clin Pract
; 98(3): c73-8, 2004.
Article
em En
| MEDLINE
| ID: mdl-15528940
ABSTRACT
BACKGROUND:
We determined the urinary levels of vascular endothelial growth factor (VEGF) in patients with reflux nephropathy to elucidate its clinical significance as a predictor of the development of renal damage. PATIENTS ANDMETHODS:
Seventy-two patients (47 boys and 25 girls) aged 10-18 years with reflux nephropathy were studied. Vesicoureteral reflux was resolved surgically in all cases at least 2 years before enrollment. Urinary VEGF, alpha1-microglobulin and albumin levels were determined using morning spot urine samples. Plasma VEGF, serum creatinine and beta2-microglobulin levels were measured simultaneously. The severity of renal scarring and right and left kidney function were assessed by 99mTc dimercaptosuccinic acid renal scan.RESULTS:
No significant correlation was found between the plasma and urinary VEGF levels. Urinary VEGF increased significantly with the increase in severity of renal scarring (p < 0.0001). Urinary VEGF levels correlated significantly with serum beta2-microglobulin (p < 0.002) and urinary alpha1-microglobulin (p < 0.03). No significant correlation of urinary VEGF levels with serum creatinine and urinary albumin levels was found. Nearly 60% of the patients with elevated urinary VEGF had normal levels of serum beta2-microglobulin and/or urinary alpha1-miocroglobulin.CONCLUSIONS:
Urinary VEGF level appears to reflect its production in the kidney. Since urinary VEGF shows a propensity to elevate before the increase in serum beta2-microglobulin and/or urinary alpha1-microglobulin, urinary VEGF may serve as an early indicator of the development of reflux nephropathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Refluxo Vesicoureteral
/
Fator A de Crescimento do Endotélio Vascular
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nephron Clin Pract
Ano de publicação:
2004
Tipo de documento:
Article