The synthesis, antibacterial, and beta-lactamase inhibitory activity of a novel asparenomycin analog.
J Antibiot (Tokyo)
; 45(2): 240-5, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1556016
ABSTRACT
An analog, 6-(2'-hydroxyethylidene)-4 beta-methyl-1-azabicyclo[3.2.0]hept-2-ene-2- carboxylate (11), of the carbapenem beta-lactamase inhibitor, asparenomycin A, was synthesized. It possessed a spectrum of antibacterial activity that was comparable to that of asparenomycin A but was less effective as a beta-lactamase inhibitor. With ampicillin, it only exhibited a moderate level of synergy against a variety of beta-lactamase-producing organisms. Although the presence of a 4 beta-methyl group in the analog brought about a significant increase in chemical stability relative to that of asparenomycin A, it did not result in an increase in stability to kidney dehydropeptidase enzyme.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tienamicinas
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1992
Tipo de documento:
Article