Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.
Appl Environ Microbiol
; 71(1): 562-5, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15640237
ABSTRACT
In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Bacteriocinas
/
Regulação Bacteriana da Expressão Gênica
/
Lactococcus lactis
Idioma:
En
Revista:
Appl Environ Microbiol
Ano de publicação:
2005
Tipo de documento:
Article