Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross-saturation.
Biochemistry
; 44(2): 518-23, 2005 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-15641776
We have applied NMR cross-saturation with TROSY detection to the problem of precisely mapping conformational epitopes on complete protein antigen molecules. We have investigated complexes of the Fab fragments of two antibodies that have parasite inhibitory activity, bound to the important malaria vaccine candidate antigen, Plasmodium falciparum MSP1(19). The results indicate remarkable overlap between these epitopes for inhibitory antibodies, and will provide a basis for theoretical modeling of the antibody-antigen interface.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Sítios de Ligação de Anticorpos
/
Anticorpos Antiprotozoários
/
Epitopos Imunodominantes
/
Mapeamento de Epitopos
/
Proteína 1 de Superfície de Merozoito
/
Anticorpos Monoclonais
/
Antimaláricos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochemistry
Ano de publicação:
2005
Tipo de documento:
Article