Micellar electrokinetic chromatography for determination of drug partition in phospholipids.
Farmaco
; 60(1): 77-83, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15652373
ABSTRACT
The lipophilicity of pipemidic, nalidixic and oxolinic acids was determined by forming phospholipidic micelles directly in an electrophoretic capillary. Phosphatidylcholine derivatives, namely L-alpha-dilauroyl phosphatidylcholine (DLPC) or L-alpha-dimiristoyl phosphatidylcholine (DMPC), were added in the run buffer (50 mM phosphate buffer at pH 7.4). To obtain a mixed micelle, phospholipidic derivatives and sodium cholate were together added in the run buffer. Considering the increasing of migration time when phosphatidylcholine derivative is added in the run buffer, Ks can be determined and then quinolones lipophilicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Ácido Pipemídico
/
Ácido Nalidíxico
/
Ácido Oxolínico
/
Cromatografia Capilar Eletrocinética Micelar
/
Anti-Infecciosos
Idioma:
En
Revista:
Farmaco
Ano de publicação:
2005
Tipo de documento:
Article