The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats.
Int J Oral Maxillofac Surg
; 34(2): 178-84, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15695048
ABSTRACT
Bone grafts are frequently used in the treatment of bone defects. Bone harvesting can cause postoperative complications and sometimes does not provide a sufficient quantity of bone. Therefore, synthetic biomaterials have been investigated as an alternative to autogenous bone grafts. The objective of this study was to evaluate the repair of bone defects by autogenous cancellous bone grafts or porous bioceramic discs of hydroxyapatite/phosphate cement mixture. Two 5-mm diameter defects were made in the skulls of rats and filled with the bioceramic material or cancellous bone. The rats were sacrificed 2, 4, 8 and 24 weeks after surgery and tissue samples were analyzed by radiography and histology. By the 24th week, the defects filled with autogenous cancellous bone grafts or bioceramic material showed similar volumes of bone tissue within the defect. However, defects treated with bioceramic material were almost completely closed as a result of the joining of ceramic fragments and the neoformed bone tissue, while those filled with autogenous grafts showed several areas filled with connective tissue. These results indicated that the osteointegration of bioceramic fragments allowed the reconstruction of parietal bone defects without the need for a bone graft.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso Parietal
/
Materiais Biocompatíveis
/
Doenças Ósseas
/
Transplante Ósseo
/
Durapatita
/
Substitutos Ósseos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Int J Oral Maxillofac Surg
Ano de publicação:
2005
Tipo de documento:
Article