Robust formation of morphogen gradients.
Phys Rev Lett
; 94(1): 018103, 2005 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-15698137
ABSTRACT
We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Crescimento Transformadores
/
Diferenciação Celular
/
Fenômenos Fisiológicos Celulares
/
Transporte Proteico
/
Modelos Biológicos
/
Morfogênese
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2005
Tipo de documento:
Article