[Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma].
Zhonghua Zhong Liu Za Zhi
; 27(1): 38-40, 2005 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-15771797
ABSTRACT
OBJECTIVE:
To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance.METHODS:
In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR.RESULTS:
The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05).CONCLUSION:
CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma Ductal de Mama
/
Molécula 1 de Adesão de Célula Vascular
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Zhong Liu Za Zhi
Ano de publicação:
2005
Tipo de documento:
Article