[Strategies of the nasal mucous membranes for defense against infection. Current knowledge of antimicrobial peptides]. / Strategien der Nasenschleimhaut zur Infektabwehr. Aktuelle Erkenntnisse zu antimikrobiellen Peptiden.
HNO
; 53 Suppl 1: S21-5, 2005 May.
Article
em De
| MEDLINE
| ID: mdl-15798924
ABSTRACT
Infections of healthy skin or mucous membranes are rare despite constant exposure to microbial colonization. Nonspecific and specific defense mechanisms correspond in the nose the mucociliary clearance provides very effective mechanical cleaning. If this protection is insufficient, the nasal epithelium comes into close contact with microorganisms. This triggers the recently discovered production of the body's own specific antimicrobial peptides (AP). It seems that it is difficult for microorganisms to form enzyme-induced resistance to AP. This makes AP highly interesting for the development of new antibiotics. The observation that antimicrobial activity can be induced has also led to the hypothesis that natural substances may possibly stimulate endogenous AP production. If this line of defense also fails, the inflammatory cells migrate from the blood into the tissue and, with their capacity for phagocytosis, the enzymatic attack on bacteria can cause a cellular inflammatory reaction in the nasal mucous membrane.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rinite
/
Modelos Imunológicos
/
Peptídeos Catiônicos Antimicrobianos
/
Mucosa Nasal
Limite:
Humans
Idioma:
De
Revista:
HNO
Ano de publicação:
2005
Tipo de documento:
Article