Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridization.
J Neurooncol
; 72(1): 25-8, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15803371
ABSTRACT
Few studies have yielded reliable data that distinguish between ependymal neoplasms based on molecular genetic attributes. The present study utilizes chromogenic in situ hybridization (CISH), a relatively recent hybridization technique, to retrospectively examine chromosome 7-copy number in pediatric and adult ependymomas. Of the 27 hybridizations, polysomy of chromosome 7 was detected in 10 out of 15 (66%) adult ependymomas, and in only three out of 12 (25%) pediatric lesions. All myxopapillary ependymomas showed polysomy. The remaining tumors were diploid. The authors conclude that (1) there are distinct genetic subsets of ependymoma, in particular, increases in copy number of chromosome 7 are almost exclusively found in myxopapillary ependymoma, and that (2) CISH is a rapid and sensitive method of stratifying morphological variants of ependymoma and potentially other central nervous system (CNS) tumors. These results encourage further investigations with CISH on a larger scale to determine its merit as an ancillary diagnostic and prognostic tool.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ploidias
/
Neoplasias da Medula Espinal
/
Cromossomos Humanos Par 7
/
Neoplasias Encefálicas
/
Ependimoma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
J Neurooncol
Ano de publicação:
2005
Tipo de documento:
Article