Anti-ergotypic T cells in naïve rats.
J Autoimmun
; 24(3): 191-201, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15848041
ABSTRACT
T regulatory cells play an important role in regulating T cell responses. Anti-ergotypic T cells are a subset of regulatory T cells that proliferate in response to activation markers, ergotopes, expressed on activated, and not on resting syngeneic T cells. Here we report the presence of anti-ergotypic T cells in lymph nodes, spleens and thymuses of naive rats. The development of anti-ergotypic T cells appeared to be independent of antigen priming, as thymocytes from one-day old rats exhibited significant anti-ergotypic proliferative responses. The anti-ergotypic T cells were found to be of the CD8+ phenotype, and included both TCRalpha/beta+ and TCRgamma/delta+ T cells. The TCRgamma/delta+ anti-ergotypic T cells secreted IFNgamma and TNFalpha in response to activated T cells; the TCRalpha/beta+ T cells proliferated but did not secret detectable cytokines. We found that the interaction between the anti-ergotypic T cells and stimulator T cells required cell-to-cell contact between the T cells. Professional APCs were not needed. The response of the TCRalpha/beta+CD8+ anti-ergotypic T cells was MHC-I restricted and B7-CD28 dependent; the response of the TCRgamma/delta+ anti-ergotypic T cells was B7-CD28 dependent, but was not inhibited by antibodies to classical MHC-I or MHC-II molecules. The existence of anti-ergotypic T cells in naive animals suggests that these cells might have a role in the regulation and maintenance of the immune system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Autoimunidade
/
Subpopulações de Linfócitos T
/
Epitopos de Linfócito T
Limite:
Animals
Idioma:
En
Revista:
J Autoimmun
Ano de publicação:
2005
Tipo de documento:
Article