Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism.
Am J Psychiatry
; 162(5): 1003-5, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15863807
ABSTRACT
OBJECTIVE:
The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism.METHOD:
Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism.RESULTS:
The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men.CONCLUSIONS:
The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Álcool Desidrogenase
/
Alcoolismo
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Aldeído Desidrogenase
Limite:
Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
2005
Tipo de documento:
Article