Antimutagenic constituents from the thorns of Gleditsia sinensis.
Chem Pharm Bull (Tokyo)
; 53(5): 561-4, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15863930
ABSTRACT
Antimutagenic activity-guided fractionation of an extract prepared from the thorns of Gleditsia sinensis LAM. led to the isolation of one triterpenoid and four steroids, which were identified as DC-friedours-7-en-3-one (1), stigmast-4-ene-3,6-dione (2), stigmastane-3,6-dione (3), stigmasterol (4), and beta-sitosterol (5). Triterpenoid 1 was found for the first time in a natural source and the steroids 2-5 were first isolated from this plant. Stigmasterol was the most active antimutagen, showing 51.2% and 64.2% reduction of the induction factor against the mutagens MNNG and NQO, respectively, in the SOS chromotest. Some NMR data of the steroids 2 and 3 obtained have to be revised.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antimutagênicos
/
Gleditsia
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2005
Tipo de documento:
Article