Does topical GTN on the sphincter of Oddi facilitate ERCP? A double-blind randomized control trial.
Surg Endosc
; 19(7): 902-4, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15868252
ABSTRACT
BACKGROUND:
Endoscopic retrograde cholangio pancreatography (ERCP) is a technically challenging procedure. Glyceryl trinitrate (GTN) has been shown to reduce tone in the sphincter of Oddi (SO), cannulation of which is a rate-limiting factor. A double-blind randomized control trial was performed to assess whether topical GTN on the SO would facilitate cholangiography and/or bile duct cannulation.METHODS:
104 patients requiring ERCP for biliary symptoms were randomized into two groups, 52 controls pretreated with 5 ml 0.9% normal saline (NS) and 52 pretreated with 5 ml GTN (concentration 1 mg/ml).RESULTS:
There was no significant between the control group and the GTN group in primary cannulation rate (p = 0.76), time taken to cholangiography (p = 0.58), or time to cannulation (p = 0.43).CONCLUSION:
Topically administered GTN to the SO does not aid in obtaining a cholangiogram or cannulation during an ERCP.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Colangiopancreatografia Retrógrada Endoscópica
/
Nitroglicerina
/
Esfíncter da Ampola Hepatopancreática
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Surg Endosc
Ano de publicação:
2005
Tipo de documento:
Article