Antioxidant and inflammatory responses of healthy horses and horses affected by recurrent airway obstruction to inhaled ozone.
Equine Vet J
; 37(3): 243-9, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15892234
ABSTRACT
REASONS FOR PERFORMING STUDY Inhaled ozone can induce oxidative injury and airway inflammation. Horses affected by recurrent airway obstruction (RAO) have a decreased pulmonary antioxidant capacity, which may render them more susceptible to oxidative challenge. It is currently unknown whether RAO-affected horses are more susceptible to oxidative stress than those unaffected by RAO. OBJECTIVES:
To determine whether ozone exposure induces greater oxidative stress and airway inflammation in RAO-affected horses in remission than in healthy horses.METHODS:
Seven healthy control horses and 7 RAO-affected horses were exposed to 0.8 ppm ozone for 2 h at rest.RESULTS:
At baseline, bronchoalveolar lavage fluid (BALF) ascorbic acid concentrations were lower in RAO-affected horses than healthy controls. Ozone appeared to preferentially oxidise glutathione rather than ascorbic acid 6 h after exposure. Individual healthy and RAO-affected horses demonstrated oxidation of BALF glutathione after ozone exposure. Overall, RAO-affected horses did not demonstrate increased oxidative stress following ozone exposure, compared with healthy horses. Ozone did not induce significant airway inflammation in either group.CONCLUSIONS:
RAO-affected horses in remission are not more sensitive to ozone despite a decreased pulmonary antioxidant capacity. Sensitivity to ozone appears to be independent of initial pulmonary antioxidant status. POTENTIAL RELEVANCE Horses with high susceptibility to oxidative stress may benefit from antioxidant supplementation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxidantes Fotoquímicos
/
Ozônio
/
Doenças dos Cavalos
/
Cavalos
/
Pneumopatias Obstrutivas
/
Antioxidantes
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
Equine Vet J
Ano de publicação:
2005
Tipo de documento:
Article