Vitamins C and E in the latency period in women with preterm premature rupture of membranes.
Int J Gynaecol Obstet
; 90(1): 16-20, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15907848
ABSTRACT
OBJECTIVE:
To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period.METHODS:
In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration and PPROM were randomly assigned to vitamin C (500 mg/day) and vitamin E (400 IU/day) or placebo until delivery. All women received 2 doses of betamethasone in the first 24 h after admission as well as broad-spectrum antibiotic prophylaxis.RESULTS:
Important demographic, as well as clinical characteristics such as number of cases of chorioamnionitis, early neonatal sepsis, and respiratory distress syndrome, were similar in the 2 groups. A statically significant difference in the mean+/-S.D. number of days of latency was found between the groups (10.5+/-5.2 days vs. 3.5+/-4.0 days (P = 0.03).CONCLUSION:
Vitamins C and E supplementation of after PPROM is associated with a longer latency before delivery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Vitamina E
/
Ruptura Prematura de Membranas Fetais
/
Corioamnionite
/
Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Int J Gynaecol Obstet
Ano de publicação:
2005
Tipo de documento:
Article