How did the neurotransmitter cross the bilayer? A closer view.
Curr Opin Neurobiol
; 15(3): 296-304, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15919190
ABSTRACT
Plasma membrane neurotransmitter transporters for monoamines, GABA, glycine and excitatory amino acids are homologous to two sizable families of bacterial amino acid transporters. Recently, a high resolution structure was determined for a thermophilic glutamate transporter. Also, a bacterial tryptophan transporter related to the family of biogenic amine neurotransmitter transporters was functionally expressed. Structural insights from these and other bacterial transporters will help to rationalize the mechanisms for the increasingly complex functions that have been described for mammalian transporters, in addition to their modes of regulation. We touch on recent insights into the functions of neurotransmitter transporters in their physiological contexts.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Neurotransmissores
/
Bicamadas Lipídicas
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Neurobiol
Ano de publicação:
2005
Tipo de documento:
Article