[Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen]. / Ritm sinteza belka v kul'turakh gepatotsitov krys raznogo vozrasta. Norma i deistvie peptida livagena.
Izv Akad Nauk Ser Biol
; (5): 517-21, 2001.
Article
em Ru
| MEDLINE
| ID: mdl-15926314
ABSTRACT
The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively. The peptide lyvagen (Lys-Glu-Asp-Ala) obtained by directed chemical synthesis on the basis of amino acid analysis of the liver polypeptide preparations increased the level of protein synthesis in the hepatocytes from rats of different ages; the highest effect was observed in the cells of old animals. In old rats, lyvagen increased the amplitude of protein synthesis fluctuations. The peptide epitalon (Ala-Glu-Asp-Gly) constructed on the basis of analysis of the epiphysis peptides did not change the intensity of protein synthesis in the cultured hepatocytes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Biossíntese de Proteínas
/
Relógios Biológicos
/
Hepatócitos
Limite:
Animals
Idioma:
Ru
Revista:
Izv Akad Nauk Ser Biol
Ano de publicação:
2001
Tipo de documento:
Article