Ral GTPases: corrupting the exocyst in cancer cells.
Trends Cell Biol
; 15(6): 327-32, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15953551
ABSTRACT
The Ras-like small G-proteins RalA and RalB have achieved some notoriety as components of one of a growing variety of candidate Ras effector pathways. Recent work has demonstrated that Ral GTPase activation is required to support both the initiation and maintenance of tumorigenic transformation of human cells. The mechanistic basis for this support remains to be defined. However, the discovery that the exocyst is a direct effector complex for activated Ral proteins suggests that mobilization of polarized exocytosis might be a basic component of the biological framework supporting tumorigenic progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas ral de Ligação ao GTP
/
Exocitose
/
Proteínas de Membrana
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2005
Tipo de documento:
Article