Zinc inhibition of calmodulin: a proposed molecular mechanism of zinc action on cellular functions.
Am J Hematol
; 7(1): 53-60, 1979.
Article
em En
| MEDLINE
| ID: mdl-159621
ABSTRACT
Calcium stimulates, and zinc inhibits, a wide variety of cell types. In the erythrocyte, we have found calcium and zinc to have antagonist actions in a variety of systems. An important mechanism for calcium effects on cells is activation of calmodulin. Calmodulin is a small ubiquitous protein which, when activated by calcium, has a large array of cellular regulatory functions. We now report that calmodulin function is inhibited by low concentrations of zinc. Zinc inhibition of calmodulin provides a rational molecular mechanism for the diverse cellular inhibitory effects of zinc, as well as for zinc's antagonism of calcium effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Proteínas de Ligação ao Cálcio
/
Calmodulina
/
Membrana Eritrocítica
/
Eritrócitos
Limite:
Humans
Idioma:
En
Revista:
Am J Hematol
Ano de publicação:
1979
Tipo de documento:
Article