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[Pharmacokinetic analysis of enterohepatic circulation of piroxicam in rabbits].
Zhou, H W; Shen, J Q; Lu, M; Liang, W Q; Lin, W; Zhao, W H.
Afiliação
  • Zhou HW; Devision of Biomathematics, Zhejiang Medical University, Hangzhou, China.
Zhongguo Yao Li Xue Bao ; 13(2): 180-2, 1992 Mar.
Article em Zh | MEDLINE | ID: mdl-1598837
The concentration (c)-time (t) curves of piroxicam showed double peaks following iv 10 mg dose to 4 rabbits. A new mathematical model of enterohepatic circulation was proposed to explain this double-peak phenomenon and showed good agreement with data. This model provides not only the common pharmacokinetic parameters: T1/2 = 1.12 +/- 0.32 h, V1 = 0.64 +/- 0.12 L, AUC = 34.7 +/- 7.8 micrograms.h-1.ml-1, but also the parameters of enterohepatic circulation of piroxicam: the cycling amount of drug Db = 3.9 +/- 1.4 mg, reabsorption fraction Fb = 0.50 +/- 0.04, reabsorption rate constant Ka = 2.55 +/- 0.50 h-1. It is indicated in this study that enterohepatic circulation results in a 20% average increase of the effective amount of piroxicam.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piroxicam / Circulação Êntero-Hepática Limite: Animals Idioma: Zh Revista: Zhongguo Yao Li Xue Bao Ano de publicação: 1992 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piroxicam / Circulação Êntero-Hepática Limite: Animals Idioma: Zh Revista: Zhongguo Yao Li Xue Bao Ano de publicação: 1992 Tipo de documento: Article