The evaluation of 186Re-labeled antibodies using N2S4 chelate in vitro and in vivo using tumor-bearing nude mice.
Int J Rad Appl Instrum B
; 19(2): 205-12, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1601674
ABSTRACT
We have recently described a method for radiolabeling monoclonal antibodies, with metallic radionuclides using a new chelating agent N2S3. Using this chelate the monoclonal antibodies Lym-1 and B72.3 were labeled with 186Re and their biological integrity was evaluated in vitro and in vivo. 186Re-labeled antibodies using N2S4 methodology were found to be stable in human serum and retained their immunoreactivity. Intravenous administration of 0.5 mCi 186Re-labeled antibodies resulted in partial or complete regression of tumor tissue in mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioisótopos
/
Rênio
/
Compostos de Sulfidrila
/
Imunotoxinas
/
Etilenodiaminas
/
Neoplasias Experimentais
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Int J Rad Appl Instrum B
Ano de publicação:
1992
Tipo de documento:
Article