In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata.

Oliveira, E R; Fothergill, A W; Kirkpatrick, W R; Coco, B J; Patterson, T F; Redding, S W

Oliveira, E R; Fothergill, A W; Kirkpatrick, W R; Coco, B J; Patterson, T F; Redding, S W.

Afiliação

Oliveira ER; Department of General Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. oliveirae@uthscsa.edu

Antimicrob Agents Chemother ; 49(8): 3544-5, 2005 Aug.

Article em En | MEDLINE | ID: mdl-16048980

ABSTRACT

ABSTRACT

Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

Assuntos

Antifúngicos/farmacologia; Candida glabrata/efeitos dos fármacos; Peptídeos Cíclicos/farmacologia; Triazóis/farmacologia; Candida glabrata/isolamento & purificação; Candidíase Bucal/microbiologia; Caspofungina; Farmacorresistência Fúngica; Sinergismo Farmacológico; Equinocandinas; Fluconazol/farmacologia; Humanos; Lipopeptídeos; Testes de Sensibilidade Microbiana/métodos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Triazóis / Candida glabrata / Antifúngicos Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2005 Tipo de documento: Article

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