Balancing diversity and tolerance: lessons from patients with systemic lupus erythematosus.
J Exp Med
; 202(3): 341-4, 2005 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-16061723
ABSTRACT
The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Autoimunidade
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Tolerância Imunológica
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Lúpus Eritematoso Sistêmico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2005
Tipo de documento:
Article