The elastin connection and melanoma progression.
Anticancer Res
; 25(4): 2617-25, 2005.
Article
em En
| MEDLINE
| ID: mdl-16080502
ABSTRACT
Matrikines, i.e. matrix fragments with cytokine-like properties, have been ascribed a major role in regulating tumour progression. The invasive front of melanoma is characterised by intense fragmentation of dermal elastic fibres. Elastase-mediated elastolysis liberates elastin fragments, i.e. elastokines, that stimulate several aspects of melanoma progression such as to enhance melanoma cell invasion through type I collagen or increase angiogenesis. Induced-membrane-type 1 metalloprotease (MT1-MMP) expression following elastin receptor (S-Gal) occupancy by elastokines is responsible for those biological activities. Several matrix-derived peptides with a GXXPG consensus sequence adopting a type VIII beta-turn conformation were as potent as elastokines in promoting angiogenesis in a Matrigel assay, and galectin-3 also contains several similar repeats within its N-terminal domain. We propose that S-Gal might constitute a novel therapeutic target for controlling melanoma progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Elastina
/
Melanoma
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2005
Tipo de documento:
Article