Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis.
Br J Dermatol
; 153(3): 591-5, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16120148
ABSTRACT
BACKGROUND:
Interleukin (IL)-19, a member of the IL-10 family, signals through the IL-20R1/IL-20R2 heterodimer, which is shown to be involved in abnormal keratinocyte differentiation and proliferation. Little is known about its in vitro biological functions or its role in psoriasis.OBJECTIVES:
To investigate the role of IL-19 in the psoriatic process.METHODS:
The expression of keratinocyte growth factor (KGF) transcripts was measured by polymerase chain reaction in CD8+ T cells treated with IL-19. Next, we developed monoclonal and polyclonal antibodies to measure the levels of IL-19 in the sera of patients with psoriasis and healthy volunteers using an enzyme-linked immunosorbent assay. In addition, we performed immunohistochemical staining on psoriatic skin and normal controls.RESULTS:
We found that IL-19 upregulated KGF transcripts on CD8+ T cells. Patients with psoriasis had a lower level of IL-19 in serum than healthy volunteers. The difference between these two groups was statistically significant (P < 0.05). IL-19 expression was seen in basal and suprabasal keratinocytes in a continuous pattern, and was increased in psoriatic epidermis.CONCLUSIONS:
These results suggest that IL-19 plays a role in the complex pathological cytokine network in psoriasis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Interleucina-10
/
Linfócitos T CD8-Positivos
/
Epiderme
/
Fatores de Crescimento de Fibroblastos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2005
Tipo de documento:
Article