Coagulation system activated in Duchenne muscular dystrophy patients with cardiac dysfunction.
Brain Dev
; 27(6): 415-8, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16122628
ABSTRACT
We investigated basic abnormalities of coagulation and fibrinolysis in Duchenne muscular dystrophy (DMD) patients with cardiac dysfunction. Forty seven patients with DMD, aged 13-37 years old, were enrolled. Based on left ventricular ejection fraction (LVEF) results determined by echocardiography, patients were divided into 3 groups LVEF less than 30% (markedly depressed group), LVEF between 30 and 50% (slightly depressed), and LVEF greater than 50% (normal). We measured serum levels of total fibrin and fibrinogen degradation products (FDP), as well as plasma fibrinogen, thrombin-antithrombin complex (TAT), prothrombin fragment (F1+2), and D-dimer. The levels of TAT and F1+2 in the markedly depressed group were significantly elevated compared with the other groups, whereas FDP, fibrinogen, and D-dimer levels did not differ among the groups. We concluded that activated coagulation is associated with cardiac dysfunction in patients with DMD.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Trombose Coronária
/
Cardiomiopatia Dilatada
/
Distrofia Muscular de Duchenne
Limite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Brain Dev
Ano de publicação:
2005
Tipo de documento:
Article