Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.

Fukasawa, Yutaka; Kawamura, Ikuo; Uchiyama, Ryosuke; Yamamoto, Kazuhiro; Kaku, Taijin; Tominaga, Takanari; Nomura, Takamasa; Ichiyama, Satoshi; Ezaki, Takayuki; Mitsuyama, Masao

Fukasawa, Yutaka; Kawamura, Ikuo; Uchiyama, Ryosuke; Yamamoto, Kazuhiro; Kaku, Taijin; Tominaga, Takanari; Nomura, Takamasa; Ichiyama, Satoshi; Ezaki, Takayuki; Mitsuyama, Masao.

Afiliação

Fukasawa Y; Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Japan.

Infect Immun ; 73(10): 7051-5, 2005 Oct.

Article em En | MEDLINE | ID: mdl-16177391

ABSTRACT

ABSTRACT

Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.

Assuntos

Citocinas/metabolismo; Mycobacterium tuberculosis/efeitos dos fármacos; Estreptomicina/farmacologia; Animais; Camundongos; Mycobacterium tuberculosis/metabolismo; Tuberculose/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estreptomicina / Citocinas / Mycobacterium tuberculosis Limite: Animals Idioma: En Revista: Infect Immun Ano de publicação: 2005 Tipo de documento: Article

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