Rapamycin analogs with reduced systemic exposure.

Wagner, Rolf; Mollison, Karl W; Liu, Luping; Henry, Cynthia L; Rosenberg, Teresa A; Bamaung, Nwe; Tu, Noah; Wiedeman, Paul E; Or, Yatsun; Luly, Jay R; Lane, Benjamin C; Trevillyan, James; Chen, Yung-Wu; Fey, Thomas; Hsieh, Gin; Marsh, Kennan; Nuss, Merrill; Jacobson, Peer B; Wilcox, Denise; Carlson, Richard P; Carter, George W; Djuric, Stevan W

Wagner, Rolf; Mollison, Karl W; Liu, Luping; Henry, Cynthia L; Rosenberg, Teresa A; Bamaung, Nwe; Tu, Noah; Wiedeman, Paul E; Or, Yatsun; Luly, Jay R; Lane, Benjamin C; Trevillyan, James; Chen, Yung-Wu; Fey, Thomas; Hsieh, Gin; Marsh, Kennan; Nuss, Merrill; Jacobson, Peer B; Wilcox, Denise; Carlson, Richard P; Carter, George W; Djuric, Stevan W.

Afiliação

Wagner R; Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. rolf.wagner@abbott.com

Bioorg Med Chem Lett ; 15(23): 5340-3, 2005 Dec 01.

Article em En | MEDLINE | ID: mdl-16185865

RESUMO

The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.

Assuntos

Antirreumáticos/química; Antirreumáticos/farmacocinética; Artrite Reumatoide/metabolismo; Sirolimo/análogos & derivados; Animais; Antirreumáticos/toxicidade; Artrite Reumatoide/diagnóstico por imagem; Artrite Reumatoide/tratamento farmacológico; Masculino; Radiografia; Ratos; Ratos Endogâmicos Lew; Ratos Sprague-Dawley

Buscar no Google

Imprimir

XML

PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Antirreumáticos / Sirolimo Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2005 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links