Phelligridimer A, a highly oxygenated and unsaturated 26-membered macrocyclic metabolite with antioxidant activity from the fungus Phellinus igniarius.
Org Lett
; 7(21): 4733-6, 2005 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-16209522
ABSTRACT
[structure see text] A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 microM) but was inactive to several human cancer cell lines (IC50 > 50 microM) and enzymes PTP1B (IC50 > 25 microM) and thrombin (IC50 > 10 microM).
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Basidiomycota
/
Peroxidação de Lipídeos
/
Compostos Macrocíclicos
/
Antioxidantes
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2005
Tipo de documento:
Article