The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease.
Clin Exp Immunol
; 142(2): 333-40, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16232221
ABSTRACT
Various experimental models suggest that the cholesterol-lowering drugs statins may also modulate immune responses. Cellular level studies on human disorders are needed, however, to provide a rational basis for clinical testing of statins as immune therapy. Coeliac disease, a chronic small intestinal inflammation driven by HLA-DQ2 restricted mucosal T cells that are specific for ingested wheat gluten peptides, is in many ways ideal for this purpose. In addition, there is a need for alternative treatment to the gluten-free diet in this disorder. Here we have assessed the effects of atorvastatin on gluten-reactive T cells, dendritic cells and the coeliac mucosa by in vitro culture of biopsies. Atorvastatin inhibited gluten-induced proliferation and specific cytokine production of human intestinal gluten-reactive T cell clones and lines. Dendritic cells exposed to atorvastatin displayed a reduced expression of the costimulatory molecule CD83 upon maturation with lipopolysaccharide. Incubation of intestinal biopsy specimens with atorvastatin in vitro, however, did not influence gluten-induced cytokine release. In conclusion, atorvastatin has specific effects on isolated gluten-reactive T cells and dendritic cells, but does not shut down the gluten-induced production of proinflammatory cytokines in intestinal biopsies.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Linfócitos T
/
Doença Celíaca
/
Glutens
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Ácidos Heptanoicos
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Anticolesterolemiantes
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2005
Tipo de documento:
Article