Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi.
J Med Virol
; 77(4): 522-7, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16254959
ABSTRACT
The human caliciviruses (HuCVs), including Norovirus and Sapovirus, are recognized causes of acute gastroenteritis in children and adults. A 1-year study was undertaken in Blantyre, Malawi, to examine the prevalence, and genetic diversity, of human caliciviruses (HuCVs) amongst children under 5 years of age hospitalized with acute gastroenteritis. Using the reverse transcription-polymerase chain reaction (RT-PCR), combined with nucleotide sequencing of the RT-PCR products, HuCVs were detected in 34/398 (8.5%) of children. Twelve (35.3%) of the children were co-infected with additional enteric viruses (predominantly rotavirus). The HuCVs comprised 26 Noroviruses (6.5%) and 8 Sapoviruses (2.0%). Each of the Noroviruses belonged to genogroup II, and could be further classified into six genotypes, including GII/3 (18 strains), GII/4 (2 strains), GII/11 (1 strain), GII/13 (1 strain), GII/16 (2 strains), and a putative new genotype GII/20 (2 strains). Each of the Sapoviruses belonged to genogroup GIII. HuCVs are the second most commonly identified viral enteropathogens (after rotavirus) among hospitalized children with gastroenteritis in Malawi.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caliciviridae
/
Infecções por Caliciviridae
/
Gastroenterite
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Humans
/
Infant
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2005
Tipo de documento:
Article