The Chilean AIDS cohort: a model for evaluating the impact of an expanded access program to antiretroviral therapy in a middle-income country--organization and preliminary results.
J Acquir Immune Defic Syndr
; 40(5): 551-7, 2005 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-16284531
ABSTRACT
Chile, middle-income country with 15 million people, began an expanded access program (EAP) to antiretroviral therapy (ART) in 2001. EAP provides ART, monitoring, and funding for management of associated complications in 32 points of care. A national cohort (Chilean AIDS Cohort [ChiAC]), enrolling 98% of these patients, was created for standardized treatment and impact evaluation. Information exchange is mainly through the Internet. By December 2004, the ChiAC had 4365 participants (83.3% male). At baseline, 47.5% had clinical AIDS, 26.2% were asymptomatic, 80.2% had a CD4 count <200 cells/mm and 58.2% were ART naive; in these patients, the most frequent regimen is zidovudine, lamivudine, and efavirenz. A 6-month follow-up in 1057 patients showed a global mortality of 5% (0.5% if patients were asymptomatic at baseline and 8.3% if patients had baseline AIDS). There was a similar risk of death if the baseline CD4 count was 100 to 200 cells/mm or >200 cells/mm ( approximately 1%), but this increased to 4.8% (relative risk [RR] = 5.2) and 10.7% (RR = 11.5) if the CD4 count was 51 to 100 cells/mm or
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Coleções:
01-internacional
Contexto em Saúde:
10_ODS3_salud_sexual_reprodutiva
/
2_ODS3
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Avaliação de Programas e Projetos de Saúde
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Infecções por HIV
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Fármacos Anti-HIV
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Acessibilidade aos Serviços de Saúde
Tipo de estudo:
Etiology_studies
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Evaluation_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Sysrev_observational_studies
Aspecto:
Determinantes_sociais_saude
/
Implementation_research
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
America do sul
/
Chile
Idioma:
En
Revista:
J Acquir Immune Defic Syndr
Ano de publicação:
2005
Tipo de documento:
Article