Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist.
Eur J Pharmacol
; 527(1-3): 44-51, 2005 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-16310181
ABSTRACT
This study used behavioural and in vivo electrophysiological paradigms to examine the effects of systemic and spinal administration of a bradykinin B1 receptor antagonist, compound X, on acute nociceptive responses in the rat. In behavioural experiments, compound X significantly increased the latency to withdraw the hindpaw from a radiant heat source after both intravenous and intrathecal administration, without affecting motor performance on the rotarod. In electrophysiological experiments, both intravenous and direct spinal administration of compound X attenuated the responses of single dorsal horn neurones to noxious thermal stimulation of the hindpaw. These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Medula Espinal
/
Medição da Dor
/
Antagonistas de Receptor B1 da Bradicinina
/
Amidas
/
Naftalenos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2005
Tipo de documento:
Article