NMDA receptors mediate consolidation of contextual memory in the hippocampus after context preexposure.
Neurochem Res
; 30(11): 1407-11, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16341937
ABSTRACT
Male Wistar rats received bilateral infusions of vehicle (VEH) or aminophosphonopentanoic acid (AP5), an N-metil-D-aspartate (NMDA) receptor antagonist, into the dorsal hippocampus immediately after inhibitory avoidance (IA) training. Intrahippocampal infusion of AP5 blocked 24 h IA retention. In the second experiment, animals were preexposed to the IA training context 24 h prior to training and received an infusion of either VEH or AP5 immediately after the preexposure trial and a second infusion of VEH or AP5 immediately after IA training. AP5 did not affect retention in animals preexposed to the IA box and given VEH after preexposure, but blocked retention when given after both preexposure and training. AP5 impaired retention in rats preexposed to an environment distinct from the IA box. These results suggest that NMDA receptors in the dorsal hippocampus mediate the formation of a contextual representation of the task environment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
/
Receptores de N-Metil-D-Aspartato
/
Hipocampo
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2005
Tipo de documento:
Article