Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk.
J Dent Res
; 85(1): 74-8, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16373685
ABSTRACT
Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Trombose
/
Extração Dentária
/
Mediadores da Inflamação
/
Cardiopatias
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Dent Res
Ano de publicação:
2006
Tipo de documento:
Article