[Development of immunopathology in patients with yersinia infection].

ABSTRACT

AIM: To evaluate clinical significance of changes in IL-6 concentration and neopterin in peripheral blood of patients for prognosis of the course and outcome of yersinia infection (YI). MATERIAL AND METHODS: Clinical examination and laboratory tests, 1-5-year follow-up were conducted in 68 patients with a cyclic, recurrent and lingering course of the disease. IL-6 and neopterin concentrations were measured in the course of the disease. RESULTS: Dynamic control over IL-6 concentrations in the blood of patients with yersinia infection provides information predicting the disease course and prognosis. Blood concentrations of neopterin are of help in prognostication of long-term outcomes of acute infection. CONCLUSION: Pathological syndromes forming in acute stage of yersinia infection are related to interleukin-dependent immunopathology.