Entamoeba histolytica: comparison of the role of receptors and filamentous actin among various endocytic processes.
Exp Parasitol
; 113(2): 91-9, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16458294
ABSTRACT
Entamoeba histolytica is the causative agent of amoebic dysentery. Uptake of iron is critical for E. histolytica growth and iron-bound human transferrin (holo-transferrin) has been shown to serve as an iron source in vitro. Although a transferrin-binding protein has been identified in E. histolytica, the mechanism by which this iron source is taken up by this pathogen is not well understood. To gain insight into this process, the uptake of fluorescent-dextran, -holo-transferrin, and human red blood cells (hRBCs) was compared. Both dextran and transferrin were taken up in an apparent receptor-independent fashion as compared to hRBCs, which were taken up in a receptor-mediated fashion. Interestingly, the uptake of FITC-dextran and FITC-holo-transferrin differentially relied on an intact actin cytoskeleton suggesting that their internalization routes may be regulated independently.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Endocitose
/
Entamoeba histolytica
/
Eritrócitos
/
Ferro
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Parasitol
Ano de publicação:
2006
Tipo de documento:
Article