Potent algicides based on the cyanobacterial alkaloid nostocarboline.
Org Lett
; 8(4): 737-40, 2006 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-16468755
ABSTRACT
[structure see text] Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values >or=100 nM against the growth of Microcystis aeruginosa PCC 7806, Synechococcus PCC 6911, and Kirchneriella contorta SAG 11.81, probably via the inhibition of photosynthesis. The natural product hybrid nostocarboline/ciprofloxacin displayed additional antibacterial activity against several Gram-negative bacteria (MICs >or=0.7 microM). Nostocarboline can thus be considered a potent, selective, readily available, natural algicide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Carbolinas
/
Microcystis
/
Synechococcus
/
Clorófitas
/
Alcaloides
/
Anti-Infecciosos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2006
Tipo de documento:
Article