Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo.
J Med Chem
; 49(4): 1450-4, 2006 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-16480281
ABSTRACT
We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein direct genistein analogues (2-H isoflavones), 2-carboethoxy isoflavones, and the precursor deoxybenzoins were all evaluated. Excellent in vitro activity against Cryptosporidium parvum was observed for both classes of isoflavones in cell cultures, and the lead compound 19, RM6427, shows high in vivo efficacy against an experimental infection.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Cryptosporidium parvum
/
Coccidiostáticos
/
Isoflavonas
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2006
Tipo de documento:
Article