[Preventive effect of trans-resveratrol on hypertension-induced cardiac hypertrophy in partially nephrectomized rats].
Wei Sheng Yan Jiu
; 34(6): 756-8, 2005 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-16535856
ABSTRACT
OBJECTIVE:
To investigate the effect of trans-resveratrol on hypertension-induced cardiac hypertrophy and its potential mechanisms involving endothelin (ET), angiotensin II (AngII) and nitric oxide (NO).METHODS:
Animal models bearing cardiac hypertrophy were replicated in male SD rats following partially nephrectomy (PNX). 10 mg/kg bw or 50 mg/kg bw of resveratrol was administered to rats by gavage, respectively, for 4 weeks. PNX control and sham-operation control (SHAM) were simultaneously established. Systolic pressure of rats was measured through tail at baseline and it, as well as heart weight, was measured after 4-week treatment. Serum ET-1 and AngII concentrations were determined using radioimmunological assay and NO using nitric acid reductase method.RESULTS:
After 4-week treatment, animals in PNX control group had significantly higher systolic pressure and heart weight, higher ET-1 and AngII concentrations while lower NO concentrations, compared with those in SHAM group (P < 0.05). Rats treated with 50 mg/kg bw of resveratrol had significantly lower systolic pressure and heart weight, lower ET-1 concentrations while higher NO concentrations, compared with animals in PNX group (P < 0.05).CONCLUSION:
Trans-resveratrol could protect against the increase of systonic pressure and subsequent cardiac hypertrophy in vivo, which mechanisms might, at least partly, involve with its modulation on NO, AngII and ET.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Fármacos Cardiovasculares
/
Cardiomegalia
/
Hipertensão
Limite:
Animals
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Ano de publicação:
2005
Tipo de documento:
Article