Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists.
Bioorg Med Chem Lett
; 16(10): 2724-8, 2006 May 15.
Article
em En
| MEDLINE
| ID: mdl-16540318
ABSTRACT
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected the oral bioavailability. Potent and orally available CXCR2 antagonists are herein reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Receptores de Interleucina-8B
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2006
Tipo de documento:
Article