Thymic microenvironments for T cell differentiation and selection.
Nat Immunol
; 7(4): 338-43, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16550196
ABSTRACT
The adult thymus provides a variety of specialized microenvironments that support and direct T cell differentiation and selection. In this review, we summarize recent advances in the understanding of the function of microenvironments in shaping a diverse T cell repertoire. In particular, we focus on how thymocytes move in and out of these specialized thymic compartments in response to homing signals, differential chemokine gradients and other factors that regulate T cell migration. In addition, we discuss the diverse developmental signals provided by these microenvironments that contribute to the generation of divergent T cell lineages.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Linfócitos T
/
Diferenciação Celular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Ano de publicação:
2006
Tipo de documento:
Article